Scientists at Royal College of Surgeons report research in angiotensins.(Report)

According to a study from Dublin, Ireland, "Angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, and diuretics all cause reactive rises in plasma renin concentration, but particularly high levels have been reported with aliskiren. This prompted speculation that blockade of plasma renin activity with aliskiren could be overwhelmed, leading to paradoxical increases in blood pressure."

"This meta-analysis of data from 4877 patients from 8 randomized, double-blind, placebo-and/or active-controlled trials examined this hypothesis. The analysis focused on the incidence of paradoxical blood pressure increases above predefined thresholds, after >= 4 weeks of …